Welcome to Dilaforette

Introduction

Anopheles gambiae mosquito feedingDilaforette is currently developing a new drug for treatment of severe malaria patients. There are 250 million malaria cases per year resulting in close to one million deaths, mostly children. Despite antimalarial treatment, 10 percent or more of the patients with severe malaria die. Low anticoagulant heparin (LAH) is a potential new adjunctive treatment of severe malaria that acts by preventing and reversing the infected cells’ ability to block blood vessels.

Background

Dilaforette was founded by leading scientists in malaria from Karolinska Institute and leading experts in the field of heparin and drug development from Uppsala University and the Swedish pharmaceutical industry together with Karolinska Innovation AB.

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  • News

    • Dilaforette – Phase II study with sevuparin for the treatment of severe malaria initiated

      2013-01-30 13:48:26 STOCKHOLM – January 30, 2013. Dilaforette, a Karolinska Development portfolio company, today announces that the company has approval from the regulatory authority in India to start a Phase II study with sevuparin in patients with moderate to severe malaria.   Dilaforette and its collaborator, The Mahidol Oxford Tropical Medicine Research Unit (MORU), plan to enroll 50 patients in India, where severe malaria remains an important problem. The primary objective of the study is to evaluate safety along with several efficacy parameters. The

    • Dilaforette is granted SEK 2.85m for development of sevuparin for the treatment of severe malaria

      2012-11-02 07:37:02 STOCKHOLM – November 2, 2012. Dilaforette announces today that it has been granted SEK 2.85m from the Swedish Governmental Agency for Innovation Systems, Vinnova, for the development of sevuparin, a new potential treatment for severe malaria.   Sevuparin is intended as an adjunctive therapy to anti-parasite medicines in order to prevent the infected red blood cells from obstructing blood vessels and thereby reducing mortality. Each year nearly 10 million people are diagnosed with severe malaria and about one million die of the disease. The

    • First patient has received low anticoagulant heparin (LAH) in Phase I/II

      2011-09-23 14:46:06 STOCKHOLM - September 23, 2011. Dilaforette, today announced that the first patient has received a dose of low anticoagulant heparin (LAH) in a Phase I/II study. This is the first time that low anticoagulant heparin (LAH) will be tested in malaria patients. The study is conducted in uncomplicated falciparum malaria patients with safety as the primary objective. In the next step efficacy in severe malaria patients will be tested. A total of 98 patients is planned to be included in the trial which